Born in 1975 in a musical family Denis Lupachev studied at the Special Music School of the St.-Petersburg State Conservatoire, then in Paris at the CNSM (prof. Alain Marion) and the St.-Petersburg State Conservatoire (prof. Gleb Nikitin). Afterwards had post-graduate studies in Munich at the Hochschule fur Musik of Munich (prof. Andras Adorjan), graduating in 2002.
In 1993 Denis Lupachev won the first prize at the International Festival "Virtuosi 2000" (Russia), in 1997 he received the special prize of the jury in the Kobe International Flute Competition (Japan). In 1999 - first prize at the "Leonardo de Lorenzo" International Flute Competition (Italy).
Since 1998 is the Principal flute of the Mariinsky Theatre Symphony Orchestra.
As a soloist performed with the Mariinsky Theatre Symphony Orchestra under conductors Gianandrea Noseda, Tugan Sokhiev, Mikhail Agrest. Also performed with Moscow State Chamber Orchestra, Ekaterinburg Philharmonic Orchestra, Novosibirsk Chamber Orchestra and many other orchestras in Russia.
Denis Lupachev gives recitals and chamber music concerts together with pianist Peter Laul in the St.-Petersburg Small Philharmonic Hall and the Mariinsky Concert Hall.
In 2016 organized annual Festival “Virtuosi of the Flute” in the Mariinsky Theatre which was attended by Emmanuel Pahud, Denis Bouriakov, Walter Auer, Julien Beaudiment, Matvey Demin.
In 2019 took part in the 1st Festival “Sochi Baroque and Chamber Music”.
His new recording “A Flute for the Tsar” dedicated to the Mariinsky flutists of the past has been released at ReachSound.Art in 2020.
Being the professor of the St.-Petersburg State Conservatoire Denis Lupachev gives master classes in Russia and abroad (CNSM de Paris, Geidai University in Tokyo).